Assaf Rudich

The paper identifies a feedback loop between SETD6-mediated methylation of PPARγ and lipid metabolism gene expression in liver-derived cells, linking it to lipid accumulation and disease.

The paper identifies distinct adipocyte subsets in human white adipose tissue with different metabolic profiles and links TSHZ3 to their regulation and metabolic disease associations.

This study shows that time-restricted feeding improves glucose intolerance and circadian disruption caused by weight cycling in young obese mice, but not in mid-aged mice.

This study shows that mid-aged mice normalize dysglycemia faster than young mice when reversing obesity, but their hypothalamic microgliosis worsens after diet reversal.

This study examines the effects of weight cycling on immune remodeling in metabolic tissues and finds that metabolic dysfunctions are uncoupled from inflammation in obese mice.

The paper uses snRNA-seq to analyze human subcutaneous and visceral adipose tissue, identifying classical and specialized adipocyte subtypes and depot-specific patterns.