The paper identifies a feedback loop between SETD6-mediated methylation of PPARγ and lipid metabolism gene expression in liver-derived cells, linking it to lipid accumulation and disease.

eLife · Aug 17, 2026Peer-reviewedCell Biology

Repeated fasting events sensitize enhancers, transcription factor activity and gene expression to support augmented ketogenesis

Noga Korenfeld, Meital Charni‐Natan, Justine Bruse, Dana Tamar Goldberg, Dorin Marciano-Anaki, Dan Rotaro, Tali Gorbonos, Talia Radushkevitz-Frishman, Arnaud Polizzi, Abedelmajeed Nasereddin, Ofer Gover, Meirav Bar‐Shimon, Anne Fougerat, Hervé Guillou, Ido Goldstein

The paper shows that repeated fasting events sensitize enhancers and gene expression to enhance ketogenesis in mice.

Nucleic Acids Research · Nov 6, 2024Peer-reviewedMolecular Biology

Transcriptional cascades during fasting amplify gluconeogenesis and instigate a secondary wave of ketogenic gene transcription

Dana Tamar Goldberg, Nufar Buchshtab, Meital Charni‐Natan, Ido Goldstein

The paper identifies transcriptional cascades during fasting that amplify gluconeogenesis and trigger a secondary wave of ketogenic gene transcription through hormone-induced transcription factors.

Liver International · Aug 20, 2024Peer-reviewedMolecular Biology