Michal Feldman

The paper identifies a feedback loop between SETD6-mediated methylation of PPARγ and lipid metabolism gene expression in liver-derived cells, linking it to lipid accumulation and disease.

This study shows that SETD6 methylates RAD18, affecting its localization and reducing DNA damage.

The paper investigates the role of SETD6 in mediating BRD4 and MITF interactions and genomic occupancy in melanoma cells, revealing a chromatin complex that regulates gene expression.

This study shows that SETD6 methylates Aurora-B kinase, regulating cytokinesis and preventing chromosomal instability, with implications for cancer.

The paper identifies a positive feedback loop where SETD6 methylates E2F1 at K117, enhancing SETD6 expression, and shows that this methylation is critical for maintaining SETD6 levels.

The paper shows that TWIST1 methylation by SETD6 suppresses LINC-PINT expression, reducing EMT in GBM cells.

The paper analyzes ancient genomes from Anatolia to show genetic continuity between hunter-gatherers and early farmers, suggesting limited migration in the origin of farming in central Anatolia.

This paper presents ancient DNA data from Northern Europe to reconstruct the genetic history of the region, showing earlier Anatolian farmer ancestry and the impact of steppe pastoralists.