Heterogeneity during induction of resistance delays Pseudomonas aeruginosa recovery from antibiotic exposures.
David Ritz, Rachel Martin, Mabel Bush, JoAnne Villagrana, Yijie Deng, Daniel Schultz
This study shows that Pseudomonas aeruginosa resistance to aminoglycosides is heterogeneous, with mexZ mutations improving survival by bypassing slow MexXY activation, and introduces a 'Response Dynamics' assay to measure resistance in fluctuating drug environments.
bioRxiv · Sep 20, 2024 · PreprintMicrobiology