Directing the Chondro-Fibro Axis via Early Microenvironmental Interactions to Enable Precise and Volumetric Cartilage Repair
Maddie Hasson, Hanna Solomon, Samir Chihab, Aniya Hartzler, Lorenzo M. Fernandes, Alan Zhao, William X Patton, Nyssa Morgan, Alan Y. Liu, Nazir M. Khan, Jarred M. Kaiser, Jason Tyler Bariteau, Jay Patel
This study investigates how modulating the Rho-ROCK pathway in microfracture clots can reprogram cells to promote chondrogenic rather than fibrotic repair in cartilage defects.
bioRxiv · Aug 18, 2026 · PreprintBioengineering