Author

Madeline Laramee

New York State Psychiatric Institute

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Neuroscience· 1

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Approach:experimental assay· 1

Frequent Co-Authors

Alice L. RodrigueziD· 1 shared Colleen Marie NiswenderiD· 1 shared Jonathan A. JavitchiD· 1 shared Justin B. SteinfeldiD· 1 shared Paul K. Spearing· 1 shared Wesley B. AsheriD· 1 shared Xia LeiiD· 1 shared Xin LiniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperNeuroscience

Alice L. RodriguezORCID

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1 paper

Recent·Most cited

Transmembrane Domain Dominance Drives Emergent Signaling and Allosteric Inversion in mGlu1/5 Heterodimers

Justin B. Steinfeld, Xia Lei, Madeline Laramee, Xin Lin, Alice L. Rodriguez, Paul K. Spearing, Wesley B. Asher, Colleen Marie Niswender, Jonathan A. Javitch

The paper shows that signaling in mGlu1/5 heterodimers is dominated by the mGlu protomer, leading to emergent signaling and allosteric inversion, with implications for drug design.

bioRxiv · May 22, 2026 · PreprintNeuroscience