Corruption of DNA End-Joining in Mammalian Chromosomes by Progerin Expression as Revealed by a Model Cell Culture System
Liza A. Joudeh, Alannah J. DiCintio, Madeline R. Ries, Andrew S. Gasperson, Kennedy E. Griffin, Victoria P. Robbins, Makenzie G. Bonner, Sarah Nolan, E P Black, Alan S. Waldman
This study shows that progerin expression in a mouse model shifts DNA double-strand break repair from precise ligation to error-prone non-homologous end joining, potentially contributing to genomic instability and aging.
bioRxiv · Jul 18, 2022Molecular Biology