Alan S. Waldman

The paper investigates how progerin affects DNA double-strand break repair, finding that it increases error-prone end-joining and reduces repair precision.

This study shows progerin induces DNA damage without affecting replication or cell proliferation in human cells.

This study shows that progerin expression in a mouse model shifts DNA double-strand break repair from precise ligation to error-prone non-homologous end joining, potentially contributing to genomic instability and aging.