Molecular BiologybioRxiv
Corruption of DNA End-Joining in Mammalian Chromosomes by Progerin Expression as Revealed by a Model Cell Culture System
Liza A. Joudeh, Alannah J. DiCintio, Madeline R. Ries…·Alan S. Waldman
This study shows that progerin expression in a mouse model shifts DNA double-strand break repair from precise ligation to error-prone non-homologous end joining, potentially contributing to genomic instability and aging.
9 citations