A Sulfotransferase from a Gut Microbe Acts on Diverse Phenolic Sulfate Compounds, Including Acetaminophen Sulfate
Rylee Close, Schuyler Kremer, Madison Mitchem, Andrew Bellinghiere, Khemlal Nirmalkar, Chad R. Borges, Rosa Krajmalnik‐Brown, Dhara D. Shah
This study identifies a gut microbial sulfotransferase that sulfonates diverse phenolic compounds, including acetaminophen sulfate, suggesting microbial enzymes may contribute to host detoxification.
PNAS Nexus · Dec 26, 2025Peer-reviewedBiochemistry