Development of a Serum-Free Producer Cell Line Generation Process for Scalable and Efficient rAAV Production for gene therapy applications
José Miguel Escandell, Mafalda Dias, Maria Gonçalves, Daniel A. M. Pais, Andreia Conceição, Amit Mathur, Barak Balva, Saurabh Sen, Bruno Figueroa, Karen A. Vincent, Patrícia Gomes‐Alves
This study develops a serum-free process for generating producer cell lines for scalable and efficient rAAV production, achieving productivity and quality comparable to serum-based methods.
Journal of Biotechnology · Feb 14, 2026Peer-reviewedBioengineering