Reprogramming breast cancer cells to breast cancer stem cell-like by the POU1F1 transcription factor
Leandro Ávila, Samuel Seoane, Sandra Paola Rodríguez-González, Magda Gois, M. Arias, David Martinez-Delgado, Noemí Gómez‐Lado, Tomás García‐Caballero, Pablo Aguiar, Román Pérez-Fernández
This study shows POU1F1 reprograms breast cancer cells into BCSC-like by altering key markers and activating the IL-6/JAK2/STAT3 pathway, suggesting therapeutic targeting of this pathway in hormone therapy-resistant tumors.
npj Breast Cancer · Mar 19, 2026Peer-reviewedCancer Biology