David Martinez-Delgado

The Holliday junction resolvase GEN1 preserves genome integrity and self-renewal in mouse embryonic stem cells

This study shows that GEN1 is essential for mouse embryonic stem cell self-renewal and genome stability, with a non-enzymatic role in maintaining pluripotency.

Reprogramming breast cancer cells to breast cancer stem cell-like by the POU1F1 transcription factor

This study shows POU1F1 reprograms breast cancer cells into BCSC-like by altering key markers and activating the IL-6/JAK2/STAT3 pathway, suggesting therapeutic targeting of this pathway in hormone therapy-resistant tumors.

Rapamycin reverts cavernoma endothelial cell phenotype and when combined with lapatinib ameliorates chronic lesions

This study shows rapamycin reverses gene expression in Ccm3-deficient endothelial cells and, when combined with lapatinib, reduces lesion volume in a chronic CCM model.