VPS34 regulation in pulmonary arterial vascular smooth muscle cells in pulmonary hypertension
Anthony Natoli, Benjamin Reinhard, Logan Hallee, Huan Zhang, Kaylin Piza-Taylor, Felix Aung, Andrianna Poznahovska, Jason P. Gleghorn, Rachel Lucas, Maggie DiVita, Yuanjun Shen
This study investigates VPS34 activation in pulmonary arterial vascular smooth muscle cells in pulmonary hypertension, finding it drives proliferation and fibrotic remodeling, and shows SAR405 inhibition reduces disease progression.
bioRxiv · Oct 13, 2026 · PreprintCell Biology