Yuanjun Shen

VPS34 regulation in pulmonary arterial vascular smooth muscle cells in pulmonary hypertension

This study investigates VPS34 activation in pulmonary arterial vascular smooth muscle cells in pulmonary hypertension, finding it drives proliferation and fibrotic remodeling, and shows SAR405 inhibition reduces disease progression.

TSC2-extracellular matrix crosstalk controls pulmonary vascular proliferation and pulmonary hypertension

This study shows TSC2 deficiency in pulmonary vascular smooth muscle cells leads to ECM remodeling, hyper-proliferation, and pulmonary hypertension, which can be reversed by restoring TSC2 function.

Wilson disease: intersecting DNA methylation and histone acetylation regulation of gene expression in a mouse model of hepatic copper accumulation

This study investigates how DNA methylation and histone acetylation changes in a mouse model of Wilson disease are influenced by diet and copper chelation, revealing their role in regulating gene expression in metabolic pathways.