Microglial MyD88-dependent signaling influences extracellular matrix development and interneuron maturation in the hippocampus
Julia E. Dziabis, Irene O. Jonathan, Benjamin L. Horvath, Grace Zhang, Michael S. Patton, Caroline J. W. Smith, Dang M. Nguyen, Mahika Jammula, Benjamin A. Devlin, Sarah K. Monroe, Erica J. Freeman, Antony Brayan Campos-Salazar, Madeline J. Clark, Staci D. Bilbo
This study shows that microglial MyD88 signaling affects ECM development and interneuron maturation in the hippocampus, with sex-specific effects on PVI density and behavior.
bioRxiv · Dec 11, 2025 · PreprintNeuroscience