LemonCatcher Acidic Pull-Down Enables Selective In-Cell Hydrogen-Deuterium Exchange Mass Spectrometry
Dietmar Hammerschmid, Mahjoobeh Ehsani, Anthony H. Keeble, Benjamin Russell Lewis, Valeria Calvaresi, Polina Heatley, Di Zhu, Henry Hayward, Weston B. Struwe, Paula J. Booth, Mark R. Howarth, Eamonn Reading
This paper introduces LemonCatcher and SelQueX to enable selective in-cell HDX-MS for studying protein dynamics under acidic conditions.
bioRxiv · Aug 27, 2026 · PreprintBiochemistry