Eamonn Reading

This paper introduces LemonCatcher and SelQueX to enable selective in-cell HDX-MS for studying protein dynamics under acidic conditions.

This study uses hydrogen-deuterium exchange mass spectrometry to analyze how non-peptide agonists and endogenous ligands modulate structural dynamics in a pre-coupled GLP-1R-Gs complex, revealing patterns linked to receptor activation.

The paper investigates the molecular mechanism of MdtF, an RND transporter in E. coli, revealing structural and functional adaptations for multidrug efflux under anaerobic and acidic conditions.

The paper investigates how Mg2+ and pH regulate the structural dynamics of AcrA in the AcrAB-TolC multidrug efflux pump, showing Mg2+ maintains structural mobility for optimal pump function across varying environments.