CRISPR/Cas13a powered electrochemical microfluidic biosensor for nucleic acid amplification-free miRNA diagnostics
Richard C. Bruch, Julia Baaske, Claire V. Chatelle, Mailin Meirich, Sibylle Madlener, Wilfried Weber, Can Dincer, Gerald Anton Urban
This paper introduces a CRISPR/Cas13a-powered microfluidic biosensor for rapid, low-cost miRNA detection without nucleic acid amplification, achieving a 10 pM limit of detection in 9 minutes.
Advanced Materials · Oct 30, 2019Peer-reviewedMolecular Biology