Wilfried Weber

The paper uses a tabular foundation model to predict material properties of engineered living hydrogels from genetic and process parameters, achieving high accuracy in predicting storage modulus.

This paper demonstrates genetically programmed shape-morphing in engineered living materials using enzymatic reactions to control hydrogel properties and motion.

This paper introduces a modular AAV retargeting platform using SpyTag/SpyCatcher for targeted gene delivery, demonstrating specific cancer cell transduction and therapeutic potential.

The paper develops optogenetic tools to cluster eGFP-tagged proteins and uses them to activate NF-κB signaling by clustering IKKα and IKKβ.

This study shows that formaldehyde from fixation solutions can diffuse between wells and affect cellular signaling pathways like YAP and NF-κB in adjacent cultures.

This study creates synthetic organelles that link metabolic signals to transcriptional regulation using phase separation, showing reversible control of gene expression in response to pyruvate.

This study shows that genetically programmed mechanical properties of bacterial engineered living materials modulate mechanosignaling in mammalian cells.

This study tunes the material properties of transcription factor condensates to show their impact on gene expression levels in mammalian cells and mice.

PenTag enables specific, covalent conjugation of proteins to ligands for biohybrid material synthesis, demonstrating applications in hydrogels and computational systems.

The paper designs a biohybrid materials circuit with binary decoder functionality using protease-based modules to detect small molecules and produce regulated protease outputs.

This paper develops a red light-responsive hydrogel that allows reversible control of stiffness for cell positioning in microfluidic systems.

The paper develops a material-genetic interface as a safety switch for engineered cells in hydrogels to control therapeutic agent production based on the presence of the embedding material.

This paper introduces a CRISPR/Cas13a-powered microfluidic biosensor for rapid, low-cost miRNA detection without nucleic acid amplification, achieving a 10 pM limit of detection in 9 minutes.