Disruption of the NTCP-EGFR receptor complex as a strategy for selective inhibition of hepatitis B and D virus entry
Atsuto Kusunoki, Kaho Shionoya, Frank Stappenbeck, Takeshi Morita, Hirofumi Ohashi, Makoto Nagano, Ryo Morishita, Feng Wang, Kazuhiko Katayama, Farhad Parhami, Koichi Watashi
This study identifies Oxy229, a compound that disrupts the NTCP-EGFR receptor complex, selectively inhibiting HBV and HDV entry without affecting NTCP or EGFR physiological functions.
bioRxiv · Feb 5, 2026 · PreprintMicrobiology