A Comparative Chemical-Genetic Screen Reveals Divergent Roles for Host ALK2 Signaling Across Intracellular Bacterial Niches
Sahoo Parnika, Malavika K A, Mullai Valli Ramamoorthy, Usha Krishna, Aishani Saha, Megha Manoj Menon, Ling Wei, Sandhya Ganesan, Kamalakannan Vijayan
The paper identifies ALK2 as a critical host kinase for C. burnetii replication, while C. trachomatis suppresses ALK2 signaling, revealing divergent strategies for niche exploitation.
bioRxiv · Jul 31, 2026 · PreprintMicrobiology