Macrophages drive a fibrogenic gene program of periductal fibroblasts in pediatric primary sclerosing cholangitis
Yunguan Wang, David Adeleke, Xiangfei Xie, Zi F. Yang, Annika Yang vom Hofe, Manavi Singh, Astha Malik, Ramesh Kudira, Cyd M. Castro-Rojas, Liva Pfuhler, Mosab Alquraish, Pamela B. Sylvestre, Jonathan R. Dillman, Andrew T. Trout, Emily R. Miraldi, Alexander Gerhard Miethke
This study identifies macrophage-driven fibrotic gene programs in periductal fibroblasts of PSC using multi-omics data, highlighting potential therapeutic targets.
bioRxiv · Aug 14, 2025 · PreprintImmunology