Alexander Gerhard Miethke

This study identifies macrophage-driven fibrotic gene programs in periductal fibroblasts of PSC using multi-omics data, highlighting potential therapeutic targets.

The paper identifies Gucy1α1 as a specific marker for fibroblasts in multiple organs, showing its expression increases in fibrotic conditions across mouse and human tissues.

This study shows cholestasis shifts hepatic Tregs to a Th17 phenotype and impairs their suppressor function, with bile acid levels influencing Treg activity and liver injury.

The paper links IBD polygenic risk to TNFi response using multiome-seq and genetic data from pediatric IBD patients.