Author

Xiangfei Xie

Cincinnati Children's Hospital Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:CITE-seq· 1

Frequent Co-Authors

David Adeleke· 2 shared Yunguan WangiD· 2 shared Alexander Gerhard MiethkeiD· 1 shared Andrew T. TroutiD· 1 shared Annika Yang vom HofeiD· 1 shared Astha MalikiD· 1 shared Chen-Tsung HuangiD· 1 shared Cyd M. Castro-Rojas· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBioinformatics

David Adeleke

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Author profile →

3 papers

Recent·Most cited

MisTIC: Missegmented Transcript Inference Correction for Improved Spatial Transcriptomics Analysis

Yuqiu Yang, Erica A. K. DePasquale, David Adeleke, Xiangfei Xie, Zeyu Lu, Michael D. Nelson, Guanghua Xiao, Xinlei Wang, Yunguan Wang

MisTIC corrects transcript misassignment in spatial transcriptomics data, improving cell type identification, differential expression analysis, and RNA localization.

bioRxiv · Dec 15, 2025 · PreprintBioinformatics

Macrophages drive a fibrogenic gene program of periductal fibroblasts in pediatric primary sclerosing cholangitis

Yunguan Wang, David Adeleke, Xiangfei Xie, Zi F. Yang, Annika Yang vom Hofe, Manavi Singh, Astha Malik, Ramesh Kudira, Cyd M. Castro-Rojas, Liva Pfuhler, Mosab Alquraish, Pamela B. Sylvestre, Jonathan R. Dillman, Andrew T. Trout, Emily R. Miraldi, Alexander Gerhard Miethke

This study identifies macrophage-driven fibrotic gene programs in periductal fibroblasts of PSC using multi-omics data, highlighting potential therapeutic targets.

bioRxiv · Aug 14, 2025 · PreprintImmunology

Energy-Based Systematic Modeling of Adaptive Immune Repertoire Behavior: Study on Cell Proliferation & Somatic Hypermutation process

Yexing Chen, Haiwen Ni, Yongjie Li, Jin Ma, Chen-Tsung Huang, Sixian Yang, Xiangfei Xie, Haitao Lv, Min Li, Peng Cao

This study develops a mathematical model to describe immune repertoire dynamics, including cell proliferation and somatic hypermutation, validated using mouse spleen and human PBMC data.

Fundamental Research · Jun 3, 2025Peer-reviewedBioinformatics