Characterization of prohibitins as novel target to block asexual and sexual stage growth of Plasmodium falciparum
Monika Saini, Che Julius Ngwa, Manisha Marothia, Vandana, Kailash Chand Pandey, Soumya Pati, Anand Ranganathan, Gabriele Pradel, Shailja Singh
This paper identifies prohibitins (PHBs) in Plasmodium falciparum as druggable targets, showing their mitochondrial localization and functional roles, and demonstrates that Rocaglamide inhibits parasite growth in multiple drug-resistant strains.
bioRxiv · Jun 2, 2022 · PreprintMolecular Biology