Shailja Singh

This paper shows that PfHSP70-3-SBD enhances PfCSP immunogenicity through cross-presentation, improving vaccine efficacy against malaria.

AptViralDB is a manually curated database of 1,768 experimentally validated antiviral aptamers against 40 viruses and 104 targets, offering annotations, predicted structures, and search tools.

This study identifies loss of intestinal 1,2-fucose in HIV-treated individuals as a modifiable host-microbiome mechanism linked to inflammation, barrier dysfunction, and aging.

AptCancerDB curates experimentally validated anticancer aptamers, providing a resource for discovery and development of diagnostics and therapeutics.

This study investigates neuronal differentiation and splicing defects in congenital DM1 iPSC models, revealing precocious differentiation and mis-splicing in key genes.

This study shows that degrading host p38-MAPK with NR-7h reduces parasite load in Leishmania and Plasmodium infections and enhances antiparasitic therapy when combined with Amphotericin B.

This study demonstrates the antimalarial and immunomodulatory effects of Himalayan Buransh in vitro, in vivo, and in silico, showing potential as an adjunct therapy for drug-resistant malaria.

This study identifies inflammation-responsive s-acylation of key antioxidants in microglia, revealing their role in redox flexibility and schizophrenia pathology.

This study evaluates a PROTAC molecule to degrade p38 MAPK in mosquitoes, disrupting Plasmodium falciparum development and enhancing immune gene expression, suggesting PROTACs as a novel strategy for malaria transmission control.

This paper evaluates PF-543, a SphK1 inhibitor, against Leishmania donovani, showing reduced parasite load and enhanced immune response both in vitro and in vivo.

This study identifies mosquito ferritin as a critical iron-storage protein essential for egg development and highlights its potential as a target for malaria control through iron chelation.

This study identifies SphK1 as a druggable target in human macrophages for anti-leishmanial therapy by showing its role in promoting Leishmania donovani survival through immune evasion and cell fate regulation.

This study identifies Ginsenoside Rg1 as a PfHT1 inhibitor that disrupts glucose metabolism and inhibits growth of both ART-sensitive and resistant Plasmodium falciparum parasites.

This study evaluates the immunopharmacological efficacy of Leishmania donovani overexpressing Ld_ζ1domain as a vaccine candidate against visceral leishmaniasis, showing reduced parasite burden and enhanced immune response.

This study identifies the filarial serpin Wb123 and shows it promotes macrophage alternative activation via uPAR, which is inhibited by the monoclonal antibody MAbG8.

This paper investigates how replenishing NADPH can restore redox homeostasis and lysosomal function in G6PD-deficient microglia through metabolic pathway modulation.

This paper develops a fed-batch cultivation method for Viola odorata plant cells, achieving higher biomass production and demonstrating antiplasmodial activity comparable to natural extracts.

This study shows that host PMCA4b variations affect intraerythrocytic calcium and ROS levels, reducing artemisinin sensitivity in malaria parasites.

The paper assesses the functional relevance of a Plasmodium MFS protein as a drug transporter using Candida glabrata, showing antifungal resistance and antimalarial properties.

This study shows that G6PD deficiency in microglia impairs iNOS-mediated NO production and lysosomal acidification, leading to reduced phagocytosis of SARS-CoV-2 and increased COVID-19 severity.

The paper identifies PfTSEN1 as a tRNA splicing endonuclease in Plasmodium falciparum and demonstrates its inhibition by TSENi, a novel anti-malarial compound.

This study identifies the Plasmodium prefoldin complex as essential for proteotoxic stress response and demonstrates that biperiden inhibits its function, offering a new drug target for malaria.

This study identifies a cold shock protein in Plasmodium falciparum essential for asexual and sexual stages and shows its potential as a druggable target.

This study shows that S1P from host erythrocytes regulates PfHDAC-1 activity, affecting transcription of genes related to gametocytogenesis, virulence, and proliferation in Plasmodium falciparum.

This paper identifies prohibitins (PHBs) in Plasmodium falciparum as druggable targets, showing their mitochondrial localization and functional roles, and demonstrates that Rocaglamide inhibits parasite growth in multiple drug-resistant strains.

This study shows erythritol inhibits Plasmodium falciparum growth across multiple life stages and protects the blood-brain barrier, suggesting it as a potential anti-malarial compound.

The paper reports a novel tRNA-derived peptide, tREP-18, with potent anti-leishmanial activity against L. donovani and PKDL isolates.

This paper identifies PMD as a conserved region of Plasmodium perforin-like proteins that forms pores in erythrocytes, leading to anemia, and shows that anti-PMD inhibitors block parasite growth and transmission across multiple stages.