Monika Saini

This paper evaluates PF-543, a SphK1 inhibitor, against Leishmania donovani, showing reduced parasite load and enhanced immune response both in vitro and in vivo.

This study identifies the Plasmodium prefoldin complex as essential for proteotoxic stress response and demonstrates that biperiden inhibits its function, offering a new drug target for malaria.

This study identifies a cold shock protein in Plasmodium falciparum essential for asexual and sexual stages and shows its potential as a druggable target.

This study shows that S1P from host erythrocytes regulates PfHDAC-1 activity, affecting transcription of genes related to gametocytogenesis, virulence, and proliferation in Plasmodium falciparum.

This paper identifies prohibitins (PHBs) in Plasmodium falciparum as druggable targets, showing their mitochondrial localization and functional roles, and demonstrates that Rocaglamide inhibits parasite growth in multiple drug-resistant strains.