De novo damaging coding mutations are strongly associated with obsessive-compulsive disorder and overlap with autism
Carolina Cappi, Melody E. Oliphant, Zsanett Péter, Gwyneth C. Zai, Catherine A.W. Sullivan, Abha R. Gupta, Ellen J. Hoffman, Manmeet Virdee, Arthur Jeremy Willsey, Roseli Gedanke Shavitt, Eurı́pedes Constantino Miguel, James L. Kennedy, Margaret Anne Richter, Thomas V. Fernandez
The paper identifies de novo damaging mutations in OCD and finds overlap with autism genes, suggesting shared genetic risk.
bioRxiv · Sep 21, 2017 · PreprintGenetics