James L. Kennedy

This study uses Mendelian randomization and mediation analysis to show that neuroticism's link to Alzheimer's disease is mediated by modifiable factors like depression, hypertension, and alcohol consumption, rather than being causal.

This paper identifies 58 genome-wide significant loci for major anxiety disorders using a large meta-analysis and highlights GABAergic signaling as a potential mechanism.

This study identifies genetic risk loci and factors underlying clinical subtypes of bipolar disorder using GWAS and meta-analysis.

This study identifies a four-fold enrichment of treatable genetic disorders in psychiatric patients compared to the general population through targeted sequencing of 129 genes.

This paper identifies ultra-rare de novo damaging variants in ADHD cases and finds KDM5B as a high-confidence risk gene, along with enriched biological pathways.

This paper conducts a multi-ancestry GWAS meta-analysis of suicide attempt, identifying 12 genome-wide significant loci and finding shared genetic risks with ADHD, smoking, and risk tolerance.

This study identifies genetic loci associated with suicide attempts and shows shared genetic architecture with psychiatric disorders and non-psychiatric risk factors.

This study identifies a genome-wide significant variant for OC traits and shows shared genetic risk between OC traits and OCD.

The paper estimates genetic correlations between eating disorder and substance-use-related phenotypes using GWAS data, finding both positive and negative associations.

This study finds frequent copy number variant (CNV) syndromes in schizophrenia patients and proposes a CNV-schizophrenia model linking specific phenotypes to CNVs.

This study finds enrichment of pathogenic variants linked to treatable genetic disorders in psychiatric populations, particularly in schizophrenia.

This paper uses transcriptomic imputation to identify gene-tissue associations linked to Anorexia Nervosa risk, finding significant links in both brain and metabolic tissues.

The paper identifies de novo damaging mutations in OCD and finds overlap with autism genes, suggesting shared genetic risk.

The paper reanalyzes mtDNA SNPs associated with schizophrenia in Danish populations, finding significant bi-genomic linkage disequilibrium that may confound disease associations.

The paper analyzes the spatio-temporal distribution and genogeographic affinity of mitochondrial DNA haplogroups in 24,216 Danes, finding increased frequencies of certain haplogroups linked to immigration.