Arthur Jeremy Willsey

Adrenomedullin restores human cortical interneurons migration defects induced by hypoxia

The paper shows hypoxia impairs human cortical interneuron migration and demonstrates adrenomedullin can restore this defect through the cAMP/PKA pathway.

Ciliary biology intersects autism and congenital heart disease

The paper identifies CHD genes that disrupt NPC biology and are enriched for ciliary biology, linking cilia dysfunction to ASD and CHD comorbidity.

Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility

This study shows autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility, with potential therapeutic benefits from serotonin signaling modulation.

Convergence of autism proteins at the cilium

The paper shows autism genes converge at cilia, linking them to ciliary dysfunction and co-occurring conditions.

Oxytocin receptor controls promiscuity and development in prairie voles

This study shows that the oxytocin receptor regulates specific aspects of pair bonding and promiscuity in prairie voles by controlling gene expression and neural mechanisms.

Autism genes converge on microtubule biology and RNA-binding proteins during excitatory neurogenesis

The paper represses 87 high-confidence ASD genes in a human cortical neurogenesis model, identifying 17 genes that disrupt developmental trajectory and reveal convergence on microtubule biology and RNA-binding proteins.

A foundational atlas of autism protein interactions reveals molecular convergence

The paper constructs a PPI network of 100 high-confidence ASD genes, identifies novel interactions, and uses AlphaFold-Multimer to prioritize variants for functional validation in organoids.

Pleiotropy of autism-associated chromatin regulators

The paper investigates the role of chromatin regulators in autism spectrum disorder (ASD) by examining their involvement in microtubule biology and cellular proliferation, finding that ASD risk genes affect these processes and are enriched among microtubule-associated proteins.

Rare Maternally Inherited Coding Variants on Chromosome X Carry Predominantly Male Risk in Autism, Tourette Syndrome, and Attention-deficit/Hyperactivity Disorder

Genome-wide Association Study identifies two novel loci for Gilles de la Tourette Syndrome

This study identifies two novel genetic loci associated with Tourette Syndrome through a genome-wide meta-analysis and integrates functional data to implicate specific genes.

Whole Genome Sequencing in Psychiatric Disorders: the WGSPD Consortium

The paper discusses the role of whole genome sequencing in psychiatric disorders through the WGSPD consortium, aiming to assess its utility compared to other genotyping methods.

De novo damaging coding mutations are strongly associated with obsessive-compulsive disorder and overlap with autism

The paper identifies de novo damaging mutations in OCD and finds overlap with autism genes, suggesting shared genetic risk.