A PTBP1-CDC42 splicing axis regulates leukemia growth and venetoclax sensitivity in acute myeloid leukemia
Margaux Oberling, Mathieu Landry, Yann Aubert, Manon Faivre, Alexandre Gay, Alexandre Boudet, Anais Granjon, Ambrine Sahal, Sarah Bertoli, François Vergez, Véronique Mansat‐De Mas, Christian Récher, Clément Larrue, Laura Poillet-Perez, Jean‐Emmanuel Sarry, , Margherita Ghisi
This study identifies PTBP1-CDC42 splicing regulation as a critical factor in AML growth and venetoclax sensitivity, suggesting a therapeutic combination strategy.
bioRxiv · Aug 26, 2026 · PreprintCancer Biology