Author

Manon Müller

Idorsia Pharmaceuticals Ltd (Switzerland)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1

Frequent Co-Authors

A. Mac SweeneyiD· 2 shared Geoffroy Bourquin· 2 shared Nadia Artico· 2 shared Roland Lange· 2 shared A. MetziD· 1 shared Alain ChamboveyiD· 1 shared Carina Lotz-Jenne· 1 shared Céline Potot· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

A. Mac SweeneyORCID

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2 papers

Recent·Most cited

BiochemistryScientific ReportsPeer-reviewedNov 13, 2024

Discovery and binding mode of small molecule inhibitors of the apo form of human TDO2

Carina Lotz-Jenne, Roland Lange, Sylvaine Cren…·A. Mac Sweeney

This study identifies small molecule inhibitors that bind to apo-TDO2 and inhibits its activity at low nanomolar concentrations, along with their co-crystal structures.

12 citations

humanexperimental assay

𝕏 PostBluesky

BiophysicsActa Crystallographica Section D Structural BiologyPeer-reviewedJan 18, 2024

Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket

Chia‐Ying Huang, A. Metz, Roland Lange…·A. Mac Sweeney

This study identifies 29 fragment hits against SARS-CoV-2 main protease using X-ray crystallography, including two covalent binders, and shows crystal form affects fragment binding poses.

17 citations

experimental assaydrug response / drug discovery

𝕏 PostBluesky