Author

Sylvaine Cren

Idorsia Pharmaceuticals Ltd (Switzerland)ORCID 0009-0001-3131-7831Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

A. Mac SweeneyiD· 1 shared Carina Lotz-Jenne· 1 shared Christoph Joesch· 1 shared Geoffroy Bourquin· 1 shared Laksmei Goglia· 1 shared Manon Müller· 1 shared Micha WickiiD· 1 shared Nadia Artico· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

A. Mac SweeneyORCID

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1 paper

Recent·Most cited

BiochemistryScientific ReportsPeer-reviewedNov 13, 2024

Discovery and binding mode of small molecule inhibitors of the apo form of human TDO2

Carina Lotz-Jenne, Roland Lange, Sylvaine Cren…·A. Mac Sweeney

This study identifies small molecule inhibitors that bind to apo-TDO2 and inhibits its activity at low nanomolar concentrations, along with their co-crystal structures.

12 citations

humanexperimental assay

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