NAD metabolism plays multiple roles in influenza A virus replication in a novel ex vivo model of mouse lung infection.
Florentine Jacolin, Anne Aublin‐Gex, Manon Vellet, Didier Décimo, Maxime Lepetit, Lola Canus, Eva Ogire, Adeline Cezard, Clémence Jacquemin, Séverine Croze, Joël Lachuer, Guillaume Marcy, Olivier Diaz, Vincent Lotteau, Pierre‐Olivier Vidalain, , Laure Perrin‐Cocon
This study shows that NAD metabolism is critical for influenza A virus replication in an ex vivo mouse lung model, with PARP inhibition reducing viral production.
bioRxiv · Oct 14, 2025 · PreprintMicrobiology