Targeted Reduction of Pathogenic Heteroplasmy Through Binding of G-Quadruplex DNA
Mansur M. Naeem, Rathena Maheshan, Sheila R. Costford, Brett A. Kaufman, Neal Sondheimer
This study shows that small-molecule G-quadruplex binders can reduce pathogenic mtDNA heteroplasmy in fibroblasts, increasing complex I protein levels.
bioRxiv · Jun 28, 2018 · PreprintGenetics