Author

Sheila R. Costford

Hospital for Sick ChildrenORCID 0000-0001-8328-1853Unclaimed ORCID profile · follow to get notified of new preprints

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

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Brett A. KaufmaniD· 1 shared Mansur M. Naeem· 1 shared Neal SondheimeriD· 1 shared Rathena Maheshan· 1 shared

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2018-2018 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperGenetics

Brett A. KaufmanORCID

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1 paper

Recent·Most cited

GeneticsbioRxivPreprintJun 28, 2018

Targeted Reduction of Pathogenic Heteroplasmy Through Binding of G-Quadruplex DNA

Mansur M. Naeem, Rathena Maheshan, Sheila R. Costford…·Neal Sondheimer

This study shows that small-molecule G-quadruplex binders can reduce pathogenic mtDNA heteroplasmy in fibroblasts, increasing complex I protein levels.

2 citations

humanDNA methylation

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