Heat-killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide promote longevity by modulating aging hallmarks and enhancing immune responses in Caenorhabditis elegans
Arun Kumar, Manti Kumar Saha, Vipin Kumar, Anupam Bhattacharya, Sagar Barge, Ashis Kumar Mukherjee, Mohan Chandra Kalita, Mojibur R. Khan
This study shows that heat-killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide extend C. elegans lifespan by improving proteostasis and immune responses through modulation of insulin-like signaling, autophagy-lysosome pathway, and antioxidant defenses.
Immunity & Ageing · Aug 2, 2024Peer-reviewedMicrobiology