From Single-Cell Emergent Behaviors to Clinical Outcome: PTEN-driven Migratory Efficiency as a Potential New Vulnerability in Glioblastoma
Mariangela Morelli, Gianmarco Ferri, Francesca Lessi, Francesca Di Lorenzo, Sara Franceschi, Francesca Marchetto, Gabriele Tancreda, Tiziano Vadi, Francesco Sarnari, Tim Hohmann, Francesco Pieri, Carlo Gambacciani, Francesco Pasqualetti, Yawer Hussain Shah, Jace Singh, , Chiara Maria Mazzanti
This study identifies PTEN gain-of-function mutations as linked to increased migratory efficiency in glioblastoma cells, correlating with poorer patient survival.
bioRxiv · Mar 20, 2026 · PreprintCancer Biology