Controlled Blood-Brain Barrier Modulation by a High-Affinity Claudin-5 Peptide Binder
Alessandro Berselli, Martina Trevisani, Giulio Alberini, Aldo Pastore, Andrea Di Fonzo, Andrea Armirotti, Valentina Castagnola, Luca Maragliano, Fabio Benfenati
The paper designs a high-affinity CLDN5 peptide binder, ST9, that induces reversible, size-controlled BBB openings without altering CLDN5 expression or proteomic profile.
bioRxiv · Sep 18, 2026 · PreprintNeuroscience