PARylation in Parkinson's disease: a bridge between Lewy body formation and neuronal cell death
Claudia Novello, Federica Giampietro, Alessandra Maria Calogero, Giorgio Giaccone, Michele Salemi, Manuela Bramerio, Emanuela Bonoldi, Daniela Calandrella, Elena Contaldi, Ioannis U. Isaias, Chiara Rolando, Gianni Pezzoli, Graziella Cappelletti, Samanta Mazzetti
This study investigates the role of PARylation in Parkinson's disease by analyzing post-mortem brain samples, finding PAR accumulation precedes α-synuclein aggregation and contributes to Lewy body formation and neuronal cell death.
Cell Death and Disease · Jun 23, 2026Peer-reviewedNeuroscience