This study investigates the role of PARylation in Parkinson's disease by analyzing post-mortem brain samples, finding PAR accumulation precedes α-synuclein aggregation and contributes to Lewy body formation and neuronal cell death.

Cell Death and Disease · Jun 23, 2026Peer-reviewedNeuroscience

Linking acetylated alpha-Tubulin redistribution to alpha-Synuclein pathology in brain of Parkinson's disease patients

Samanta Mazzetti, Federica Giampietro, Alessandra Maria Calogero, Huseyin Berkcan Isilgan, Gloria Gagliardi, Chiara Rolando, Francesca Cantele, Miriam Ascagni, Manuela Bramerio, Giorgio Giaccone, Ioannis U. Isaias, Gianni Pezzoli, Graziella Cappelletti

The paper investigates acetylated alpha-Tubulin redistribution in Parkinson's disease brains and links it to alpha-Synuclein pathology and Lewy body formation.

npj Parkinson s Disease · Jan 2, 2024Peer-reviewedNeuroscience

CXCR4 involvement in neurodegenerative diseases

Luke W. Bonham, Celeste M M. Karch, Chun Chieh Fan, Chin Hong Tan, Ethan G. Geier, Yunpeng Wang, Natalie Wen, Iris Broce, Yi Li, Matthew J. Barkovich, Raffaele Ferrari, John Hardy, Parastoo Momeni, Günter U. Höglinger, Ulrich Müller, , Murray Grossman

The paper identifies a genetic variant near CXCR4 associated with increased risk for PSP and PD, showing dysregulation of CXCR4 and microglia-related genes in neurodegenerative diseases.

Translational Psychiatry · Apr 11, 2018Peer-reviewedGenetics

Immune-related genetic enrichment in frontotemporal dementia

Iris Broce, Celeste M M. Karch, Natalie Wen, Chun Chieh Fan, Yunpeng Wang, Chin Hong Tan, Naomi Kouri, Owen A. Ross, Günter U. Höglinger, Ulrich Müller, John Hardy, Parastoo Momeni, Christopher Paul Hess, William P. Dillon, Zachary Miller, , John Collinge

This study identifies genetic overlaps between frontotemporal dementia and immune-mediated diseases, finding strong enrichment with rheumatoid arthritis and moderate enrichment with other immune conditions.

PLoS Medicine · Jan 9, 2018Peer-reviewedGenetics