The lipid A acylation pattern of Coxiella burnetii prevents detection and clearance by the non-canonical inflammasome in primary murine macrophages
Manuela Szperlinski, Faiza Asghar, František Csicsay, Elias Schermuly, Roland Lang, Ľudovít Škultéty, Christian Berens, Katja Mertens‐Scholz, Anja Lührmann
This paper shows that Coxiella burnetii uses its lipid A acylation pattern to avoid activating the non-canonical inflammasome in macrophages, thereby evading immune detection and clearance.
PLoS Pathogens · Jul 24, 2026Peer-reviewedImmunology