Genetic identification of the RAS proteostatic machinery and its failure to regulate oncogenic variants
Johannes W. Bigenzahn, Felix Kartnig, Manuela Vollert, Vitaly Sedlyarov, Giulio Superti‐Furga
The paper identifies genetic modules regulating KRAS proteostasis and shows that the oncogenic KRAS G12D mutant is less regulated by CRL3LZTR1, contributing to cancer progression.
bioRxiv · Dec 11, 2025 · PreprintCell Biology