Vitaly Sedlyarov

Genetic identification of the RAS proteostatic machinery and its failure to regulate oncogenic variants

The paper identifies genetic modules regulating KRAS proteostasis and shows that the oncogenic KRAS G12D mutant is less regulated by CRL3LZTR1, contributing to cancer progression.

Metabolic mapping of the human solute carrier superfamily

The paper systematically evaluates the metabolic and transcriptional effects of SLC superfamily members, identifying new substrates and functional groups.

Data- and knowledge-derived functional landscape of human solute carriers

The paper creates a functional landscape of human solute carriers by integrating multi-omics data and curated knowledge, assigning functions to each SLC and providing a web-accessible resource.

A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery

The paper performs a genome-wide CRISPR/Cas9 knock-out screen to identify genes involved in phagocytosis, validates key complexes, and maps their functional roles in human cells.

Critical role of PCYT2 in muscle health and aging

This study identifies PCYT2 as critical for muscle health and aging, showing its deficiency causes muscle weakness and aging, and demonstrates therapeutic potential through AAV-based delivery.