Author

Johannes W. Bigenzahn

CeMM Research Center for Molecular MedicineORCID 0000-0002-5214-4570Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Felix KartnigiD· 1 shared Giulio Superti‐FurgaiD· 1 shared Manuela Vollert· 1 shared Vitaly SedlyaroviD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperCell Biology

Felix KartnigORCID

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1 paper

Recent·Most cited

Cell BiologybioRxivPreprintDec 11, 2025

Genetic identification of the RAS proteostatic machinery and its failure to regulate oncogenic variants

Johannes W. Bigenzahn, Felix Kartnig, Manuela Vollert…·Giulio Superti‐Furga

The paper identifies genetic modules regulating KRAS proteostasis and shows that the oncogenic KRAS G12D mutant is less regulated by CRL3LZTR1, contributing to cancer progression.

DOI 10.64898/2025.12.10.693430

humanproteomics

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