Author

Manzar Alam

The University of Texas Southwestern Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Debanjan SarkariD· 1 shared Diego H. CastrillóniD· 1 shared Esra A. AkbayiD· 1 shared Hasan ZakiiD· 1 shared He ZhangiD· 1 shared Md. Kawsar Mustofa· 1 shared Mitzi Aguilar· 1 shared Mohammad Basher· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Debanjan SarkarORCID

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1 paper

Recent·Most cited

Inflammation is an essential trigger for POLE-driven ultramutated colorectal cancer

Md. Kawsar Mustofa, Mitzi Aguilar, He Zhang, Debanjan Sarkar, Sambit Roy, Manzar Alam, Mohammad Basher, Subhransu Sahoo, Esra A. Akbay, Diego H. Castrillón, Hasan Zaki

This study shows that inflammation triggers POLE-mutant colorectal cancer in mice, revealing inflammation as a key driver and establishing a preclinical model for drug discovery.

bioRxiv · Oct 20, 2026 · PreprintCancer Biology