Esra A. Akbay

Inflammation is an essential trigger for POLE-driven ultramutated colorectal cancer

This study shows that inflammation triggers POLE-mutant colorectal cancer in mice, revealing inflammation as a key driver and establishing a preclinical model for drug discovery.

Cancer Cachexia in STK11/LKB1-mutated NSCLC is Dependent on Tumor-secreted GDF15

This study shows that tumor-secreted GDF15 drives cachexia in STK11/LKB1-mutated NSCLC, and blocking GDF15 reduces cachexia symptoms in mice.

Coordinated translational control of multiple immune checkpoints by the integrated stress response pathway in lung cancer

The paper shows that the integrated stress response (ISR) coordinates the translation of PD-L1 and CD155, two immune checkpoint proteins, in lung cancer, and suggests combining ISR inhibition with PD-1 blockade as a therapeutic strategy.

A novel and potent MICA/B antibody is therapeutically effective in KRAS LKB1 mutant lung cancer models

This paper develops a novel MICA/B-targeting antibody that enhances NK cell activity and shows therapeutic efficacy in KRAS LKB1 mutant lung cancer models.