RNA and protein are not interchangeable in single-cell spatial multi-omics
Sergi Cervilla, Daniela Grases, Noelia Montesdeoca, Albert Font Pous, Maria Fernández-Saorin, Olatz Etxaniz, Juan Carlos Pardo, María Ochoa-de-Olza, Mariona Figols, Núria Sala, Claudia Fina, María Rodriguez, Juan Pablo de-Torres, María D. Lozano, Luis M. Montuenga, , Eduard Porta‐Pardo
This study shows that spatial RNA and protein measurements are largely overlapping for lineage markers and abundance but discordant for specific molecules and spatial features, indicating they are complementary rather than interchangeable.
bioRxiv · Oct 6, 2026 · PreprintCancer Biology