Carlos E. de Andrea

RNA and protein are not interchangeable in single-cell spatial multi-omics

This study shows that spatial RNA and protein measurements are largely overlapping for lineage markers and abundance but discordant for specific molecules and spatial features, indicating they are complementary rather than interchangeable.

UMITIC: An unsupervised framework for the joint characterization of cellular phenotypes and spatial neighborhoods in multiplex and hyperplex immunofluorescence imaging data

UMITIC is an unsupervised framework that characterizes cellular phenotypes and spatial neighborhoods in multiplex imaging data, showing improved accuracy over existing methods.

ATF4 programs proline-dependent immune evasion in β-Catenin-driven hepatocellular carcinoma

This study identifies ATF4 as a key driver of immune evasion in β-catenin-driven hepatocellular carcinoma by programming a proline-dependent metabolic axis that suppresses anti-tumor immunity.

Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS-chemokine-myeloid axis

This study shows that chromosomal instability in esophageal adenocarcinoma drives an inflammatory tumor microenvironment through a cGAS-chemokine-myeloid axis, with CXCL8 as a key mediator.